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Role of cell adhesions in neural development : ウィキペディア英語版 | Role of cell adhesions in neural development Cellular adhesions can be defined as proteins or protein aggregates that form mechanical and chemical linkages between the intracellular and extracellular space. Adhesions serve several critical processes including cell migration, signal transduction, tissue development and repair. Due to this functionality, adhesions and adhesion molecules have been a topic of study within the scientific community. Specifically, it has been found that adhesions are involved in tissue development, plasticity, and memory formation within the central nervous system (CNS), and may prove vital in the generation of CNS-specific therapeutics. ==Adhesion classifications==
* Cell-cell adhesions provide chemical and mechanical connections between adjacent cells. Of special importance to neuronal tissue development are the subcategory n-cadherins. These cadherin molecules have been shown to be important in formation of the CNS structure, as well as neuronal migration along glial fibers. * Cell-Extra-Cellular Matrix (ECM) adhesions also form mechanical and chemical linkages, but the connection occurs between cellular-matrix and the extra-cellular matrix through a plethora of adhesive proteins that form cohesive functional units. These focal adhesion plaques are highly dynamic in nature and undergo a maturation process through which they have altered functionality and protein content. Maturation stages are summarized in the following table:
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